SIMONA BARONCHELLI

Researcher specialized in Applied Genetic

EDUCATION

2008-2011: PhD in Neuroscience. PhD School in Experimental and Clinical Medical Sciences, University of Milan-Bicocca, Monza, MB, Italy. (Diploma: December 2011).

2006-2008: Master of Science Degree in Medical Biotechnology, Curriculum in Experimental Medicine. School of Medicine and Surgery, University of Milan-Bicocca, Monza, MB, Italy. (Diploma: October 2008). Score: 110/110 cum laude.

2003-2006: Bachelor of Science Degree in Biotechnology. School of Mathematics, Physics and Natural Sciences, University of Milan-Bicocca, Milano, Italy. (Diploma: October 2006). Score: 110/110 cum laude.

2003: High-school. Liceo Scientifico A. Banfi, Vimercate, MB, Italy

PROFESSIONAL EXPERIENCE

September 2013 – to date: Post-Doctoral Research Associate in the Stem Cell laboratory of Dr. Ida Biunno at Institute for Genetic and Biomedical Research, National Research Council (IRGB-CNR), Milan, Italy

June 2012 – September 2013: Postdoctoral Research Scientist. Dr. Ida Biunno’s lab at Science and Technology Park, IRCCS MultiMedica, Milan, Italy.

April – May 2012: Training in molecular biology techniques. Prof. Donatella Barisani’s Lab, Department of Experimental Medicine, University of Milan-Bicocca, Monza, MB, Italy.

November 2008 – March 2012: PhD research work under the supervision of Prof. Leda Dalprà and Dr. Angela Bentivegna, Laboratory of Medical Genetics, Department of Neuroscience and Biomedical Technologies, University of Milan-Bicocca, Monza, MB, Italy. Admitted with full fellowship to the three-year PhD Program in Neuroscience.

November 2007 – October 2008: Master of Science Degree internship.Laboratory of Prof. Leda Dalprà, Operational Unit of Pathological Anatomy, Laboratory of Medical Genetics, S. Gerardo Hospital, Monza, MB, Italy.

January 2006 – October 2006: Bachelor of Science Degree internship.Laboratory of Prof. Raffaella Meneveri, with the supervision of Dr. Silvia Brunelli, Department of Experimental Medicine, University of Milan-Bicocca, Monza, MB, Italy.

PUBLICATIONS

Epigenetic and transcriptional modulation of WDR5, a chromatin remodeling protein, in Huntington’s disease human induced pluripotent stem cell (hiPSC) model.
Baronchelli S, La Spada A, Ntai A, Conforti P, Redaelli S, Bentivegna A, De Blasio P, Biunno I. Submitted.

Epigenetic targeting of glioma stem cells: Short-term and long-term treatments with valproic acid modulate DNA methylation and differentiation behavior, but not temozolomide sensitivity.
Riva G, Butta V, Cilibrasi C, Baronchelli S, Redaelli S, Dalprà L, Lavitrano M, Bentivegna A. Oncol Rep. 2016;35(5):2811-24.

DNA methylation profiles of human pluripotent stem cells, a versatile tool to investigate cell identity and biosafety.
Baronchelli S, Biunno I. Insight in Stem Cells. 2016,2,1:13.

Investigating DNA methylation dynamics and safety of human embryonic stem cell differentiation towards striatal neurons.
Baronchelli S, La Spada A, Conforti P, Redaelli S, Dalprà L, De Blasio P, Cattaneo E, Biunno I. Stem Cells Dev. 2015;24(20):2366-77.

Biobanking shifts to “precision medicine”.
Ntai A, Baronchelli S, Pellegrino T, De Blasio P, Biunno I. J Biorep Sci Appl Med. 2014;2:11-15.

In vitroanticancer drug test: A new method emerges from the model of glioma stem cells.
Riva G, Baronchelli S, Paoletta L, Butta V, Biunno I, Lavitrano ML, Bentivegna A, Dalprà L. Toxicology Reports. 2014;188–199.

Down-modulation of SEL1L, an unfolded protein response and endoplasmic reticulum-associated degradation protein, sensitizes glioma stem cells to the cytotoxic effect of valproic acid.
Cattaneo M, Baronchelli S, Schiffer D, Mellai M, Caldera V, Saccani GJ, Dalprà L, Daga A, Orlandi R, DeBlasio P, Biunno I.J Biol Chem. 2014;289(5):2826-38.

Delineating the cytogenomic and epigenomic landscapes of glioma stem cell lines.
Baronchelli S, Bentivegna A, Redaelli S, Riva G, Butta V, Paoletta L, Daga A, Marubbi D, Cattaneo M, Biunno I, Dalprà L. PLoS One. 2013;8(2):e57462.

From cytogenomic to epigenomic profiles: monitoring the biologic behaviour of in vitro cultured human bone marrow mesenchymal stem cells.
Redaelli S, Bentivegna A, Foudah D, Miloso M, Redondo J, Riva G, Baronchelli S, Dalprà L, Tredici G. Stem Cell Res Ther. 2012;3(6):47.

Investigating the role of X chromosome breakpoints in premature ovarian failure.
Baronchelli S, Villa N, Redaelli S, Lissoni S, Saccheri F, Panzeri E, Conconi D, Bentivegna A, Crosti F, Sala E, Bertola F, Marozzi A, Pedicini A, Ventruto M, Police MA, Dalprà L. Mol Cytogenet. 2012 Jul 16;5(1):32.

Cytogenetics of premature ovarian failure: an investigation on 269 affected women.
Baronchelli S, Conconi D, Panzeri E, Bentivegna A, Redaelli S, Lissoni S, Saccheri F, Villa N, Crosti F, Sala E, Martinoli E, Volontè M, Marozzi A, Dalprà L.J Biomed Biotechnol. 2011;2011:370195.

Chromosome territories, X;Y translocation and Premature Ovarian Failure: is there a relationship?
Lissoni S, Baronchelli S, Villa N, Lucchini V, Betri E, Cavalli P, Dalprà L. Mol Cytogenet. 2009;2:19.

Distinct pools of cancer stem-like cells coexist within human glioblastomas and display different tumorigenicity and independent genomic evolution.
Piccirillo SG, Combi R, Cajola L, Patrizi A, Redaelli S, Bentivegna A, Baronchelli S, Maira G, Pollo B, Mangiola A, DiMeco F, Dalprà L, Vescovi AL. Oncogene.2009;28(15):1807-1811.