Integrated Systems Engineering Srl, (ISE for short) was established on April 24th 1996, from Pasquale De Blasio and other shareholders (mainly coming from Kontron Instruments SpA pf Milan).
In year 2000 Pasquale De Blasio (present CEO and MD) and Ida Biunno (present Scientific Director) acquired 100% the shares and re-focalized the company.
From year 2005 up to know ISE has become one of the world leader in Tissue Microarrayer instruments design and manufacturing. The Galileo Tissue Microarrayer Family represents the must appreciated TMA instrument on the market.
ISE in 2010 with a partnership agreement with BioRep, entered in the Research Grants Market. In particular ISE develops for BioRep the research activities for the following research grants:

1. NEUROscreen (EU-FP6)
2. NeuroStemCell (EU FP7)
3. ATP-SKE (ATP MIUR-Lombardy Region)

ISE operates in close collaboration with University and Public Research Groups (CNR, ISS, NIH/NCI, CNIO, etc.), International organizations (Coriell Institute for Medical Research, etc.) and Private Industries (BioRep, Euroclone, Kedrion, Chart MVE, etc.).

Activities:
The main activities of ISE are:

1. Medical Research Instrumentation design, manufacture and distribution
2. Stem Cells Quality Control and Banking (in collaboration with BioRep)

Achievements:

1. 1998 Perfusion Hypertermia Bladder Tumour Therapy System (Functional model)
2. 2007 Tissue Microarray Galileo CK 3000
3. 2008 Tissue Microarray Galileo CK 3500
4. 2009 Hybridization System XBLOT 1000
5. 2010 Tissue Microarray Galileo CK 4500
6. 2011 Tissue Microarray Galileo CK 2000 (NEW)

Mission and Goals
ISE is a Biotechnology and Bio-Engineering SME, which operates in the area of Knowledge Management and Engineering Services with the following missions:

1. Develop advanced automated instrumentation for Research.
2. Offer advanced quality control services in the area of Stem Cell Banking (in collaboration with BioRep), including iPS cells for Pharma use.

The goal of ISE are:

1. To become world leader in Tissue Microarrays development.


2. To be the European Stem Cells Banking lead Provider (in collaboration with BioRep) for Neuronal and iPS cells for Research and Pharma applications.

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