G179

Description

Organism: Homo sapiens, human

Cell Type: Glioma stem cell

Source: Adult glioblastoma multiforme (giant cell variant, 56 year-old male)

Datasheet: available under request

References:

1. Pollard SM, Yoshikawa K, Clarke ID, Danovi D, Stricker S, Russell R et al. Glioma stem cell lines expanded in adherent culture have tumor-specific phenotypes and are suitable for chemical and genetic screens. Cell Stem Cell 2009; 4: 568–580.

2. Agnihotri S, Wolf A, Munoz DM, Smith CJ, Gajadhar A, Restrepo A, Clarke ID, Fuller GN, Kesari S, Dirks PB, McGlade CJ, Stanford WL, Aldape K, Mischel PS,Hawkins C, Guha A. A GATA4-regulated tumor suppressor network represses formation of malignant human astrocytomas. J Exp Med. 2011 Apr 11;208(4):689-702.

3. Baronchelli SBentivegna ARedaelli SRiva GButta VPaoletta LIsimbaldi GMiozzo MTabano SDaga AMarubbi DCattaneo MBiunno IDalprà L. Delineating the cytogenomic and epigenomic landscapes of glioma stem cell lines. PLoS One 2013;8(2):e57462.

4. Danovi D, Folarin A, Gogolok S, Ender C, Elbatsh AM, Engström PG, Stricker SH, Gagrica S, Georgian A, Yu D, U KP, Harvey KJ, Ferretti P, Paddison PJ, Preston JE, Abbott NJ, Bertone P, Smith A, Pollard SM. A high-content small molecule screen identifies sensitivity of glioblastoma stem cells to inhibition of polo-like kinase 1. PLoS One. 2013 Oct 30;8(10):e77053.

5. Gangoso E, Thirant C, Chneiweiss H, Medina JM and Tabernero A. A cell-penetrating peptide based on the interaction between c-Src and connexin43 reverses glioma stem cell phenotype. Cell Death Dis. 2014 Jan 23;5:e1023.